PC Rathi and Dr. KR Biyani
When it comes to creating a sustained-release formulation for oral consumption, hydrophilic matrices are an interesting option to consider. They can be used for controlled release of both water-soluble and water-insoluble drugs. Linseed mucilage (LM) and Tamarind seed polysaccharide (TSP) are investigated as excipients in drug delivery systems in this study. The main aim of proposed work is to focus on the possibilities of using these polysaccharide in industries with particular reference to its physical properties, chemical properties for the formation of new drug delivery systems. During the course of this study, the objective was to develop a sustained release matrix tablet formulation of Salbutamol Sulphate for treating asthma in patients. The matrix tablets of Salbutamol Sulphate prepared by wet granulation method and evaluated for its drug release characteristics. In the presence of increased concentrations of LM, TSP, the drug release was decreased. Drug release kinetics was explained by Higuchi’s equation. Testing of the optimized formulation for stability revealed that the drug degradation was not appreciable. The results suggest that the LM and TSP can be used in the formulation of Sustained release tablets.
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