Vol. 4, Issue 1, Part A (2022)

For instance, studies have shown garlic extract achieves up to a 70% reduction in biofilm formation and a significant decrease in minimum inhibitory concentration (MIC) against *Salmonella* strains. This demonstrates its potential as a robust natural antimicrobial agent.

The rise of multidrug-resistant (MDR) Salmonella has become a significant challenge in public health and the poultry industry. The limited efficacy of conventional antibiotics necessitates the exploration of alternative therapeutic options. Garlic (Allium sativum) has shown remarkable potential as a natural antimicrobial agent due to its diverse array of bioactive compounds, including allicin, ajoene, and other sulfur-containing compounds. These components exhibit potent antibacterial properties, particularly against MDR pathogens. This review examines the therapeutic applications of garlic extract in managing MDR Salmonella, focusing on its phytochemical composition, mechanisms of action, pharmacological efficacy, synergistic effects with antibiotics, and its practical applications in poultry meat safety. Additionally, challenges in the standardization and pharmaceutical development of garlic-based therapeutics are discussed alongside future research directions.